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Title: Production of pseudoephedrine hcl pellets in a high-shear mixer-granulator
Authors: Vertommen, J ×
Michoel, Armand
Rombaut, P
Kinget, Renaat #
Issue Date: Feb-1994
Publisher: Medpharm gmbh scientific publ
Series Title: European journal of pharmaceutics and biopharmaceutics vol:40 issue:1 pages:32-35
Abstract: Pelletization in a high shear mixer-granulator was tested as an alternative for the most widely used pelletization process, which is extrusion followed by spheronization. High dosage range pellets were produced with pseudoephedrine HCl as a model drug substance and microcrystalline cellulose as the main excipient. Strong pellets with a relatively narrow particle size distribution were produced. Two conclusions could be made. Firstly, the pseudoephedrine HCl concentration and particle size of the pellets influenced the bulk and true density; secondly, pseudoephedrine HCl was completely released from the pellets in a few minutes accordingly the Higuchi equation.
ISSN: 0939-6411
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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