Title: Comparative stability study of thymidine and (dideoxy-D-erythro-hexopyranosyl)thymine analogs monitored by capillary electrophoresis
Authors: Van Schepdael, Ann ×
Smets, K
Vandendriessche, F
Van Aerschot, Arthur
Herdewijn, Piet
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Dec-1994
Publisher: Elsevier science bv
Series Title: Journal of Chromatography A vol:687 issue:1 pages:167-173
Abstract: A capillary zone electrophoretic method was developed for monitoring the stability of hexopyranosyl analogues of thymidine. The final analytical conditions adopted were as follows: capillary, fused silica, 70 cm (62 cm to detector) x 75 mu m I.D.; background electrolyte, 20 mM sodium tetraborate (pH 10.5); voltage, 30 kV; detection, UV at 262 nm; and temperature, 15 degrees C. The performance of this analytical system is discussed. The stability study at three pH values allows to compare the stability of the analogues with that of thymidine and to investigate the influence of the configuration of the N-glycosidic bond on the rate constant of degradation.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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