Title: Stereospecific synthesis of a pentopyranosyl analog of d4t monophosphate
Authors: Perezperez, Mj
Rozenski, Jef
Herdewijn, Piet # ×
Issue Date: May-1994
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:4 issue:10 pages:1199-1202
Abstract: The synthesis of a pentopyranosyl analogue of d4T monophosphate is described. In order to obtain selectively the 1,4-cis substituted nucleoside, a new pathway was devised with the following sequence: i) Glycosylation of peracetylated D-xylose with thymine, ii) introduction of the double bond between the 2' and 3' positions, iii) inversion of the 4'-OH under Mitsunobu conditions, and iv) introduction of the phosphonomethyl moiety.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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