Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Spray drying, Solid dispersions, Amorphous, Process parameters, Formulation, Poorly soluble drugs, LOW-SOLUBILITY COMPOUNDS, DISSOLUTION RATE, PHYSICOCHEMICAL PROPERTIES, PHYSICAL STABILITY, IN-VITRO, ENHANCED SOLUBILITY, MELT EXTRUSION, AMORPHOUS DRUG, BIOAVAILABILITY ENHANCEMENT, POLYGLYCOLIZED GLYCERIDES, Animals, Chemistry, Pharmaceutical, Desiccation, Drug Compounding, Humans, Pharmaceutical Preparations, Pharmacokinetics, Solubility, Technology, Pharmaceutical, Water, 1115 Pharmacology and Pharmaceutical Sciences, 3214 Pharmacology and pharmaceutical sciences

Abstract:

Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, the solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will influence the final physical structure of the obtained solid dispersion particles. This review presents an overview of the interplay between manufacturing process, formulation parameters, physical structure, and performance of the solid dispersions with respect to stability and drug release characteristics.