Title: TRPV3: time to decipher a poorly understood family member !
Authors: Nilius, Bernd ×
Biro, Tamas
Owsianik, Grzegorz #
Issue Date: Jan-2014
Publisher: Cambridge University Press
Series Title: Journal of Physiology-London vol:592 issue:2 pages:295-304
Abstract: TThe vanilloid transient receptor potential channel TRPV3 differs in several aspects from other members of the TRPV subfamily. This Ca2+, ATP and calmodulin regulated channel constitutes a target for many natural compounds and has a unique expression pattern as the most prominent and important TRP channel in keratinocytes of the skin. Although TRPV3 is considered as a thermosensitive channel, its function as a thermosensor in the skin is challenged. Nevertheless, it plays important roles in other skin functions such as cutaneous sensations, hair development and barrier function. More recently, mutations in TRPV3 were linked with a rare genodermatosis known as the Olmsted syndrome. This review gives an overview on properties of TRPV3 and its functions in the skin and skin diseases.
ISSN: 0022-3751
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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