Title: A comparative evaluation of cone-beam computed tomography (CBCT) and micro-CT on trabecular bone structures in human mandible
Authors: Van Dessel, Jeroen
Huang, Yan
Rubira-Bullen, Izabel
Depypere, Maarten
Maes, Frederik
Jacobs, Reinhilde
Issue Date: 25-Jun-2013
Conference: International Congress Of Dento-Maxillo-Facial Radiology edition:19 location:Bergen, Norway date:22-27 June 2013
Abstract: Objectives: The main purpose of this study was to determine the accuracy of Cone Beam Computed Tomography (CBCT) for measuring the trabecular bone microstructure in comparison to micro-CT (μCT). Secondly, different CBCT scanning parameters were examined to find the lowest dose exposure parameters suitable for clinical application of bone quality assessment. Materials and methods: Eight human mandibular bone samples were scanned using six different clinical exposure protocols within (W1-3) and without water (NW1-3) by a high resolution (80 µm) CBCT (Accuitomo, Japan), and were subsequently scanned by the SkyScan 1174® μCT system (SkyScan, Belgium). After scanning images were acquired, same volume of interest (VOI) of the trabecular structure were aligned to each other, using registration software based on mutual information. Segmentation were then performed and the morphometric parameters were quantified within the VOIs by CTAn software (CTAnalyser, Belgium). Descriptive statistical analysis and multiple comparison between all protocols were applied in R software. Results: No significant differences between NW (1-3) and W (1-3) protocols were observed for all variables except Statistically significant differences (α=0.05) were observed for the variable BV/TV, BS/TV, Po(tot), Tb.Th, Tb.N and Conn.dn between CBCT and µCT protocols. No significant differences were observed between all protocols for the variable Tb.Sp. High positive Pearson’s correlation coefficients were observed between CBCT and µCT protocols for all variables: BV/TV, BS/TV, Po(tot), Tb.Sp, Tb.N and Conn.dn, except for Tb.Th. Conclusion: Present study demonstrated the potential of high-resolution CBCT imaging for in vivo applications of quantitative bone morphometry and bone quality assessment. However, it must still take into account the overestimation of CBCT while measuring BV/TV, Tb.Sp, Tb.N and Tb.Th.
Description: Van Dessel J., Huang Y., Rubira-Bullen I., Depypere M., Maes F., Jacobs R., ''A comparative evaluation of cone-beam computed tomography (CBCT) and micro-CT on trabecular bone structures in human mandible'', 19th international congress of dento-maxillo-facial radiology - ICDMFR 2013, June 22-27, 2013, Bergen, Norway (Research award).
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Research Group Psychiatry
Oral Imaging
ESAT - PSI, Processing Speech and Images

Files in This Item:
File Description Status SizeFormat
3563_final.pdf Published 36KbAdobe PDFView/Open

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.