Title: Nucleosides and oligonucleotides derived from trans-4-hydroxy-N-acetyl prolinol
Authors: Ceulemans, G ×
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 1996
Publisher: Inst organic chem and biochem
Series Title: Collection of Czechoslovak Chemical Communications vol:61 pages:S234-S237
Abstract: The 4-O-phosphoramidites of monomethoxytritylated 4-hydroxy-N-[(N-6-benzoyladenin-9-yl)acetyl]prolinol and 4-hydroxy-N-[(thymin-1-yl)acetyl]prolinol were prepared for incorporation into nucleic acids. The L-trans all-adenine oligonucleotide (ON) hybridises to natural oligothymidylate, apparently via tripler formation. All-purine sequences of the L-trans form can also form homo-complexes with their pyrimidine counterpart. The D-trans compounds five larger destabilisation when inserted in DNA. D-trans all-adenine ONs do not form complexes with natural oligothymidylate. For this series of modified ONs no hybridisation could be detected between complementary strands of opposite enantiomeric form.
ISSN: 0010-0765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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