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Title: Characterization of modification sites during peptide-synthesis using liquid secondary-ion collision-induced dissociation mass-spectrometry and a computer-program
Authors: Rozenski, Jef ×
Samson, I
Janssen, Gerardus
Busson, Roger
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Nov-1994
Publisher: John wiley & sons ltd
Series Title: Organic mass spectrometry vol:29 issue:11 pages:654-658
Abstract: Side-reactions often occur during peptide synthesis resulting in modified amino acid moieties. To identify these residues, liquid secondary ion/collision-induced dissociation mass spectra were recorded. The main fragments are generated by cleavage of the peptide bond. To facilitate interpretation of the spectra and assignment of the structure, a simple, but flexible and efficient, computer program is presented. The program allows the verification of the correct structure of the synthesized peptides and the deduction of the type of side-products formed, such as alkylation of tryptophan residues.
ISSN: 0030-493X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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