Title: Analysis of buprenorphine in urine specimens
Authors: Debrabandere, L ×
Van Boven, Maurits
Daenens, Paul #
Issue Date: Jan-1992
Publisher: Amer soc testing materials
Series Title: Journal of Forensic Sciences vol:37 issue:1 pages:82-89
Abstract: The simultaneous determination of buprenorphine (Temgesic(R)) and its major metabolite, N-desalkylbuprenorphine, in urine samples has been studied. By using reversed-phase high-performance liquid chromatography (HPLC) with electrochemical detection, therapeutic concentrations of unconjugated buprenorphine down to 0.2 ng/mL, and 0.15 ng/mL for the metabolite, can be detected in urine samples. This method has been applied to a variety of urine samples from drug users. The possible analytical interference from several other regulated drugs has been studied. The results were also compared with those obtained from a commercial radioimmunoassay (RIA) test. This test is only capable of detecting buprenorphine concentrations higher than 1 ng/mL.
ISSN: 0022-1198
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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