Title: Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies
Authors: Singh, Kamaljit ×
Kaur, Hardeep
Chibale, Kelly
Balzarini, Jan #
Issue Date: Aug-2013
Series Title: European Journal of Medicinal Chemistry vol:66 pages:314-323
Article number: S0223-5234(13)00364-4
Abstract: One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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