Title: Kinetics of the hydrolysis of 2',3'-dideoxyguanosine - a potent anti-HIV agent
Authors: Van Schepdael, Ann ×
Ossembe, N
Jie, L
Herdewijn, Piet
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Jul-1991
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:73 issue:2 pages:105-110
Abstract: 2',3'-Dideoxyguanosine (ddGuo) is a potent inhibitor of the human immunodeficiency virus (HIV) in vitro. Because of the potential interest of this compound for the treatment of AIDS, its chemical stability was studied. The degradation of ddGuo in buffers of different pH and ionic strength was followed using LC. A correlation was found between the logarithm of the rate constant of degradation of ddGuo and the ionic strength of the medium, at constant pH. A pH-rate profile was constructed in the acid region using buffers of the same ionic strength. Activation parameters were determined at pH 7.0.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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