Title: Synthesis and properties of oligonucleotides containing 2,4-dihydroxycyclohexyl nucleosides
Authors: Bardiot, Dorothée ×
Rosemeyer, H
Lescrinier, Eveline
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 2005
Publisher: Wiley-v c h verlag gmbh
Series Title: Helvetica Chimica Acta vol:88 issue:12 pages:3210-3224
Abstract: Cyclohexyl nucleosides with an adenine and uracil base have been synthesized from 2-azidocyclohexane1,5-diol. The obtained racemic nucleosides were resolved using (R)-O-methylmandelic acid. Short oligonucleotides were synthesized using phorphoramidite chemistry. However, these oligonucleotides do not show self-hybridization, and duplexes are less stable than those of ribopyranosyl-(4' -> 2')-oligonucleotides.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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