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Title: Access to a new type of homo-C-nucleosides with a ''split'' 8-deazapurine via a 1,3-dipolar cycloaddition reaction
Authors: Van Calenbergh, S
De Bruyn, A
Schraml, J
Blaton, Norbert
Peeters, Oswald
De Keukeleire, D
Busson, Roger
Herdewijn, Piet # ×
Issue Date: 1997
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:16 issue:3 pages:291-300
Abstract: Upon a 1,3-dipolar addition reaction with trimethylsilyl acetylene, azides (R,S)-7 were converted to the triazoles (R,S)-8. These diastereoisomers were separated and individually protodesilylated to yield (R)- and (S)-9, fully characterized by NMR. Structural assignments of unsaturated side compounds were deduced from a QUIET-NOESY experiment. Compounds (R)-and (S)-9 represent a new type of homo-C-nucleosides with a ''split'' 8-azapurine base moiety.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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