Title: Comparison of 'classic' Tc-99m-DTPA, Tc-99m(CO)(3)-DTPA and Tc-99m(CO)(2)(NO)-DTPA
Authors: Rattat, Dirk ×
Terwinghe, C
Verbruggen, Alfons #
Issue Date: Oct-2005
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:61 issue:40 pages:9563-9568
Abstract: Diethylenetriamine pentaacetic acid (DTPA) was labeled with Tc-99m in three different ways, resulting in 'classic' Tc-99m-DTPA, Tc-99m(CO),-DTPA and Tc-99m(CO)(2)(NO)-DTPA. The biodistribution of the formed DTPA-complexes was studied in rnice with a special emphasis on the behavior of the novel tricarbonyl and dicarbonyl-nitrosyl complexes, which was clearly differing from that of 'classic' Tc-99m-DTPA. The conversion of a Tc-tricarbonyl complex to a Tc-dicarbonyl-nitrosyl complex using NO+ reagents offers a synthetic tool for preparing a novel class of Tc-99m labeled compounds. (c) 2005 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
× corresponding author
# (joint) last author

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