Title: Synthesis of 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides
Authors: Augustyns, K ×
Rozenski, Jef
Van Aerschot, Arthur
Janssen, Gerardus
Herdewijn, Piet #
Issue Date: May-1993
Publisher: Amer chemical soc
Series Title: Journal of Organic Chemistry vol:58 issue:11 pages:2977-2982
Abstract: The synthesis of 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (12)1 was accomplished using two different synthetic routes. It was obtained starting either from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose or from tri-O-acetyl-D-glucal. The other modified nucleosides, with either a cytosine, guanine, or adenine moiety, were synthesized using the second reaction scheme. Deoxygenation reactions were accomplished with the (2,4-dichlorophenoxy)thiocarbonyl derivatives generated in situ.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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