Title: Structural study of two 5-heteroaromatic-2'-deoxyuridines and their 5-bromine-heteroaromatic analogues: Theoretical conformational analysis and NMR experiments
Authors: Creuven, I ×
Lebon, F
Busson, Roger
Herdewijn, Piet
Durant, F #
Issue Date: 1997
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:16 issue:3 pages:339-346
Abstract: We have previously described that in the crystalline structure, the five membered rings of 5-thienyl and 5-furanyl 2'-dUrd have a different orientation according to the heteroatom involved (S or O). NOE difference NMR experiments were conducted in order to verify this conformation in solution. A theorical conformational analysis was further computed at the ''ab initio'' STO-3G level, to characterize the energetic profile. This comparative study realized on some 5-heteroaromatic-2'-deoxyuridines confirms the crystallographic results.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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