Title: Dissolution testing of artemisinin solid oral dosage forms
Authors: Hoa, NT ×
Michoel, Armand
Kinget, Renaat #
Issue Date: Jul-1996
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:138 issue:2 pages:185-190
Abstract: Dissolution can best be described as a tool that can provide valuable information about the bioavailability of a drug product. But to obtain a good overall correlation with in vivo data, the presence of sink conditions is an essential requirement in the dissolution tests. The flow-through cell method has been recommended to be a dissolution method that most satisfactorily fulfils this requirement for poorly water soluble drugs. The present article demonstrates that in case of artemisinin, a hydrophobic compound used in high dose per tablet or capsule, even the flow-through cell method does not guarantee the presence of sink conditions during the total duration of the experiments.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

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