International journal of pharmaceutics vol:138 issue:2 pages:185-190
Dissolution can best be described as a tool that can provide valuable information about the bioavailability of a drug product. But to obtain a good overall correlation with in vivo data, the presence of sink conditions is an essential requirement in the dissolution tests. The flow-through cell method has been recommended to be a dissolution method that most satisfactorily fulfils this requirement for poorly water soluble drugs. The present article demonstrates that in case of artemisinin, a hydrophobic compound used in high dose per tablet or capsule, even the flow-through cell method does not guarantee the presence of sink conditions during the total duration of the experiments.