Title: Evaluation of LC methods for the separation of amoxicillin and its related substances
Authors: Zhu, YX ×
Roets, Eugene
Moreno, ML
Porqueras, E
Hoogmartens, Jos #
Issue Date: 1996
Publisher: Marcel dekker inc
Series Title: Journal of liquid chromatography & related technologies vol:19 issue:12 pages:1893-1908
Abstract: Five isocratic liquid chromatography (LC) methods have been examined for the separation of amoxicillin and its related substances on C-18 or C-8 columns. The United States Pharmacopeia (USP) assay method gave better selectivity. Similar selectivity was obtained not only on C-18 columns but also on C-8 and poly(styrene-divinylbenzene) columns. The good selectivity was confirmed by a second laboratory. A resolution test using cefadroxil was developed for the method performance. Based on the USP method, a gradient LC method was developed for the analysis of related substances in amoxicillin. This method has been proposed for the assay and purity control in the amoxicillin monographs of the European Pharmacopoeia and will be further examined in a collaborative study.
ISSN: 1082-6076
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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