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Title: Enantioselective synthesis and conformational analysis of cyclohexene carbocyclic nucleosides
Authors: Wang, Jing ×
Herdewijn, Piet #
Issue Date: 1999
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:18 issue:4-5 pages:593-594
Abstract: An enantioselective approach towards the synthesis of optically pure cyclohexene nucleosides 3 has been developed starting from (R)-carvone. The key steps are the regio- and stereoselective hydroboration of an exo double bond, the selective reduction of an enone intermediate and introduction of a base moiety by Mitsunobu reaction. Conformational analysis showed that the adenine base adopts predominantly in a pseudo-axial position.
URI: 
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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