Journal of Chromatography vol:628 issue:1 pages:49-58
Isocratic column liquid chromatography on a poly(styrene-divinylbenzene) stationary phase (PLRP-S, 25 cm x 0.46 cm I.D.) at 50-degrees-C allowed the separation of cefadroxil from related substances. The mobile phase was acetonitrile-0.02 M sodium 1-octanesulphonate-0.2 M phosphoric acid-water (10.5:20:5:up to 100, v/v). The flow-rate was 1.0 ml/min and UV detection was performed at 254 nm. Official standards were compared and a number of commercial bulk samples and specialities were analysed.