Title: Oligonucleotides containing disaccharide nucleosides
Authors: Efimtseva, Ekaterina V
Bobkov, GV
Mikhailov, Sergey N
Van Aerschot, Arthur
Schepers, Guy
Busson, Roger
Rozenski, Jef
Herdewijn, Piet # ×
Issue Date: 2001
Publisher: Wiley-v c h verlag gmbh
Series Title: Helvetica Chimica Acta vol:84 issue:8 pages:2387-2397
Abstract: Disaccharide nucleosides with 2'-O-(D-arabinofuranosyl), 2'-O-(L-arabinofuranosyl), 2'-O-(D-ribopyranosyl), 2'-O-(D-erythrofuranosyl), and 2'-O-(5-azido-5-deoxy-D-ribofuranosyl) substituents were synthesized. These modified nucleosides were incorporated into oligonucleotides (see Table). Single substitution resulted in a DeltaT(m) of +0.5 to -1.4 degrees for DNA/RNA and a DeltaT(m) of - 0.8 to -4.7 degrees for DNA/DNA duplexes. These disaccharide nucleosides can be well accommodated in RNA/DNA duplexes, and the presence of a NH2- C(5") group has a beneficial effect on duplex stability.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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