Title: [M(CO)(2)(NO)](2+), a new core in bioorganometallic chemistry: model complexes of Re(CO)2(NO)(2+) and [Tc-99m(CO)(2)(NO)(2+)
Authors: Rattat, Dirk ×
Verbruggen, Alfons
Schmalle, H
Berke, H
Alberto, R #
Issue Date: May-2004
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:45 issue:21 pages:4089-4092
Abstract: In this Study selected bidentate (L-2) and tridentate (L-3) ligands were coordinated to the Re(I) or Tc(I) core [M(CO)(2)(NO)](2-) resulting in complexes of the general formula fac-[MX(L-2)(CO)(2)(NO)] and fac-[M(L-3)(CO)(2)(NO)] (M = Re or Tc: X = Br or Cl). The complexes were obtained directly from the reaction of [M(CO)(2)(NO)](2+) with the ligand or indirectly by first reacting the ligand with [M(CO)(3)](+) and subsequent nitrosylation with [NO][BF4] or [NO][HSO4]. Most of the reactions were performed with cold rhenium oil a macroscopic level before the conditions were adapted to the n.c.a. level with technetium (Tc-99m). Chloride. bromide and nitrate were Used as monodentate ligands, picolinic acid (PIC) as a bidentate ligand and histidine (HIS), iminodiacetic acid (IDA) and nitrilotriacetic acid (NTA) as tridentate ligands. We synthesised and describe the dinuclear complex [ReCl(mu-Cl)(CO)(2)(NO)](2) and the mononuclear complexes [NEt4][ReCl3(CO)(2)(NO)], [NEt4][ReBr3(CO)(2)(NO)], [ReBr(PIC)(CO)(2)(NO)]. [NMe4][Re(NO3)(3)(CO)(2)(NO)], [Re(HIS)(CO)(2)(NO)][BF4], [Tc-99(HIS)(CO)(2)(NO)][BF4], [Tc-99m(IDA)(CO)(2) (NO)] and [Tc-99m(NTA)(CO)(2)(NO)]. The chemical and physical characteristics of the Re and Tc-dicarbonyl-nitrosyl complexes differ significantly from those of the corresponding tricarbonyl compounds. (C) 2004 Elsevier Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
× corresponding author
# (joint) last author

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