Title: Evaluation of the kinetics of hydrolysis of monoamino analogs of 2'-deoxyadenosine or 3'-deoxyadenosine and of 9-(2-deoxy-beta-D-threo-pentofuranosyl)adenine or 9-(3-deoxy-beta-D-threo-pentofuranosyl)adenine by liquid-chromatography
Authors: Thoithi, G ×
Van Schepdael, Ann
Busson, Roger
Herdewijn, Piet
Roets, Eugene
Hoogmartens, Jos #
Issue Date: 1995
Publisher: Marcel dekker inc
Series Title: Nucleosides & nucleotides vol:14 issue:7 pages:1559-1579
Abstract: Liquid chromatography was used to follow the degradation of monoamino analogues of 2'- or 3'-deoxyadenosine and of 9-(2-deoxy-beta-D-threo-pentofuranosyl) adenine or 9-(3-deoxy-beta-D-threo-pentofuranosyl) adenine in buffers of different pH and constant ionic strength (mu). Comparison of stabilities of some of the compounds under study with those of corresponding hydroxyl analogues showed that at acid pH the aminated compounds are more stable than the corresponding hydroxyl compounds. The higher stability associated with the presence of an amino group in the sugar is explained in function of pK(a) values, which were determined by C-13 NMR.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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