Title: Synthesis of novel N-substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides
Authors: Vandendriessche, F ×
Voortmans, M
Hoogmartens, Jos
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Feb-1993
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:3 issue:2 pages:193-198
Abstract: Dinner building blocks (5a-j) with an N-substituted guanidine function were prepared by reaction of 5'-amino-5'-deoxythymidine (1) with S,S-dimethyl-N-substituted iminodithiocarbonimidates (2a-j) followed by reaction of the isothiourea (3a-j) with 3'-amino-3'-deoxythymidine (4). All dimers were protected at the primary hydroxyl group with a dimethoxytrityl group, converted to the phosphoramidite budding blocks and incorporated into DNA.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Pharmaceutical Analysis
× corresponding author
# (joint) last author

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