Interlaboratory study of the analysis of amoxicillin by liquid chromatography
Zhu, YX × Roets, Eugene Bruzzi, A Smelt, AJW Van der Vlies, C Betto, P Moreno, ML Porqueras, E Wendebourg, HH Sinivuo, K DeKaste, D Mayrhofer, A Graby, N Kister, G Miller, JHMcB Nap, CJ Spieser, JM Hoogmartens, Jos #
Marcel dekker inc
Journal of liquid chromatography & related technologies vol:19 issue:20 pages:3305-3314
A liquid chromatography method for analysis of amoxicillin was examined in a collaborative study involving 11 laboratories. The method comprised an isocratic part, which is used in the assay. The isocratic part is similar to the assay method for amoxicillin of the United States Pharmacopeia 23. When the isocratic part is combined with gradient elution, the method is suitable for purity control. Five samples of amoxicillin (trihydrate and sodium salt) with varying purity were analysed.