Title: Identification of a functional epitope in plasminogen activator inhibitor-1, not localized in the reactive center loop
Authors: Debrock, Sophie
Declerck, Paul # ×
Issue Date: Mar-1998
Publisher: F k schattauer verlag gmbh
Series Title: Thrombosis and haemostasis vol:79 issue:3 pages:597-601
Abstract: Plasminogen activator inhibitor-1 (PAI-1) is unique among the serpins because of its conformational flexibility. Previously, we have characterized monoclonal antibodies that neutralize PAI-1 activity by switching the active, inhibitory pathway into the non-inhibitory substrate pathway (10). Here, we report the identification of the epitopes for two of these antibodies, i.e. MA-55F4C12 and MA-33H1 and apply this information to explain their functional effects.
ISSN: 0340-6245
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Assisted Reproductive Technology Laboratory (-)
× corresponding author
# (joint) last author

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