Thrombosis and haemostasis vol:79 issue:3 pages:597-601
Plasminogen activator inhibitor-1 (PAI-1) is unique among the serpins because of its conformational flexibility. Previously, we have characterized monoclonal antibodies that neutralize PAI-1 activity by switching the active, inhibitory pathway into the non-inhibitory substrate pathway (10). Here, we report the identification of the epitopes for two of these antibodies, i.e. MA-55F4C12 and MA-33H1 and apply this information to explain their functional effects.