Title: Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloro-pyrido[4,3-d]pyrimidine scaffold
Authors: Jang, Miyeon ×
De Jonghe, Steven
Gao, Ling-Jie
Herdewijn, Piet #
Issue Date: 2006
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:47 issue:50 pages:8917-8920
Abstract: The synthesis of a 5,7-dichloropyrido[4,3-d]pyrimidine scaffold is described. The chlorine at position 5 can selectively be displaced by different palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions. In the subsequent step, the chlorine at position 7 can be further derivatized. The described synthetic sequence allows for the construction of a diverse pyrido[4,3-d]pyrimidine library with structural variations at positions 5 and 7. (c) 2006 Elsevier Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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