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Title: Synthesis of 1-[18F]fluorodeoxyglucose: an unexpected rearrangement in the reaction of 2-O-methanesulfonyl-beta-D-mannopyranose with [18F]fluoride
Authors: de Groot, Tjibbe ×
Bormans, Guy
Busson, Roger
Mortelmans, Luc
Verbruggen, Alfons #
Issue Date: Feb-1999
Publisher: John wiley & sons ltd
Series Title: Journal of labelled compounds & radiopharmaceuticals vol:42 issue:2 pages:147-157
Abstract: 2-O-Methanesulfonyl-beta-D-mannose was reacted with kryptofix/K2CO3/[F-18]fluoride in CH3CN/THF (9:1) at 60 degrees C. Unexpectedly, a mixture of 1 alpha- and 1 beta-glucopyranosyl [F-18]fluoride (4 and 5, respectively) was obtained in 50% radiochemical yield (EOB); 2-[F-18]FDG was not detected. Modification of temperature, solvent or pH did riot result in the formation of 2-[F-18]FDG. Uptake of radioactivity in heart and brain of mice was significantly lower for 4 and 5 than for 2-[F-18]FDG, although 5 seems to pass the blood-brain barrier. Uptake in bone was more pronounced for 4 than for 5 and negligible for 2-[F-18]FDG.
URI: 
ISSN: 0362-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Radiopharmacy
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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