Title: Synthesis and conformational study of 3-hydroxy-4-(hydroxymethyl)-1-cyclohexanyl purines and pyrimidines
Authors: Maurinsh, Y ×
Schraml, J
DeWinter, H
Blaton, Norbert
Peeters, Oswald
Lescrinier, Eveline
Rozenski, Jef
Van Aerschot, Arthur
De Clercq, Erik
Busson, Roger
Herdewijn, Piet #
Issue Date: May-1997
Publisher: Amer chemical soc
Series Title: Journal of Organic Chemistry vol:62 issue:9 pages:2861-2871
Abstract: The cyclohexane nucleosides with a 1,4-relationship between nucleoside base and hydroxymethyl moiety were synthesized using a conjugated addition reaction of the nucleobases to ethyl 1,3-cyclohexadiene-1-carboxylate and hydroboration of the cyclohexenyl precursor. The lack of antiviral activity of the compounds was correlated with the conformation of these nucleosides as deduced from NMR and X-ray analysis.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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