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Title: Development of synthetic strategies for the construction of pyrido[4,3-d]-pyrimidine libraries - the discovery of a new class of PDE-4 inhibitors
Authors: Jang, Miyeon
De Jonghe, Steven
Gao, Ling-Jie
Rozenski, Jef
Herdewijn, Piet # ×
Issue Date: 2006
Publisher: Wiley-v c h verlag gmbh
Series Title: European journal of organic chemistry issue:18 pages:4257-4269
Abstract: The synthesis of a pyrido[4,3-d]pyrimidine library from 4,6-diamino-2-bromonicotinamide and 4,6-diaminonicotinamide is described. A systematic variation of the substituents at positions 2, 4, 5 and 7 of the pyrido[4,3-d]pyrimidine scaffold was carried out, leading to a wide variety of structural analogues. This strategy led to the discovery of a new structural class of PDE-4 inhibitors. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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