Title: Epimerization during the coupling to the unnatural amino acid in solid phase peptide synthesis
Authors: Zhang, Zhenyu ×
Van Aerschot, Arthur
Chaltin, Patrick
Busson, Roger
Herdewijn, Piet #
Issue Date: 2001
Publisher: Inst organic chem and biochem
Series Title: Collection of Czechoslovak Chemical Communications vol:66 issue:6 pages:923-932
Abstract: Extensive epimerization was observed during the coupling of FmOC-L-Trp(Boc) and FmoC-L-Pro to D-Ual, a synthetic a-amino acid with a nucleobase in the side chain. This unnatural amino acid was used extensively in the construction of nucleic acids recognition libraries. Reaction protocols based on the use of DIC-HOAt-DIEA mixture without preactivation of the coupling mixture has been proven to suppress the epimerization reaction significantly.
ISSN: 0010-0765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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