Title: Synthesis of 1,5-anhydro-2-(N-6-cyclopentyladenin-9-yl)-2-deoxy-d-altrohexitol
Authors: Verheggen, I ×
Van Aerschot, Arthur
Pillet, N
Vanderwenden, Em
Ijzerman, A
Herdewijn, Piet #
Issue Date: 1995
Publisher: Marcel dekker inc
Series Title: Nucleosides & nucleotides vol:14 issue:3-5 pages:321-324
Abstract: The N-6-cyclopentyladenosine (CPA) analogue (4) was synthesized in 10 steps starting from glucose. The results of the radioligand binding assays are consistent with the thus far published findings that compounds containing a six-membered moiety at N-9 exhibit extremely weak affinity for adenosine receptors. Replacement of the ribofuranosyl moiety of CPA (2) by a 2-deoxy-D-altohexitol moiety is sufficient to completely abolish its agonist activity.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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