Title: Solution structure of a hexitol nucleic acid duplex with four consecutive T center dot T base pairs
Authors: Lescrinier, Eveline
Esnouf, RM
Schraml, J
Busson, Roger
Herdewijn, Piet # ×
Issue Date: 2000
Publisher: Wiley-VCH Verlag GMBH
Series Title: Helvetica Chimica Acta vol:83 issue:7 pages:1291-1310
Abstract: The structure of the hexitol nucleic acid (HNA) h(GCGCTTTTGCGC) was determined by NMR spectroscopy. This unnatural nucleic acid was developed as a mimic for A-RNA. In solution, the studied sequence is forming a symmetric double-stranded structure with four central consecutive T.T wobble pairs flanked by G.C Watson-Crick base pairs. The stem regions adopt an A-type helical structure. Discrete changes in backbone angles are altering the course of the helix axis in the internal loop region. Two H-bonds are formed in each wobble pair, and base stacking is preserved in the duplex, explaining the stability of the duplex. This structure elucidation provides information about the influence of a (T)(4) fragment on local helix geometries as well as on the nature of the T.T mismatch base pairing in a TTTT tract.
ISSN: 0018-019X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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