International Congress of Parkinson's Disease and Movement Disorders edition:17 location:Sydney, Australia date:16-21 June 2013
We investigated the involvement of cerebral white matter atrophy in the pathology of FOG. Using Diffusion Tensor Imaging (DTI), we compared the integrity of white matter tracts between 11 PD patients with FOG, 16 PD without FOG and 16 healthy controls. The main outcome, white matter volume was obtained for 1) individual tracts between subcortical seed and cortical target regions; 2) for all WM tracts through the PPN, yielding a global PPN connectivity outcome.
We found 3 FOG-related changes in WM: 1) Orbitofrontal WM volume was decreased in PD+FOG; 2) subcortico-cortical WM volume correlated to FOG severity and 3) patients with FOG had, in general, a reduced volume of WM tracts though the left PPN.
To conclude, WM atrophy in PD patients with FOG was mostly found in striato-frontal tracts and WM connections through the PPN, predominantly in the left hemisphere.
Awarded with a Travel Grant of the Movement Disorders Society (2000 USD) and an International Mobility Grant of Fonds Wetenschappelijk Onderzoek (FWO)