An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age
Vermeulen, Isabel × Weets, I Costa, O Asanghanwa, M Verhaeghen, K Decochez, K Ruige, J Casteels, Kristina Wenzlau, J Hutton, J C Pipeleers, D G Gorus, F K Belgian Diabetes Registry #
Diabetologia vol:55 issue:2 pages:413-420
The appearance of autoantibodies (Abs) before diabetes onset has mainly been studied in young children. However, most patients develop type 1 diabetes after the age of 15 years. In first-degree relatives aged under 40 years, we investigated the frequency of seroconversion to (persistent) Ab positivity, progression to diabetes and baseline characteristics of seroconverters according to age.