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Title: Synthesis and leukemia cell growth inhibition of a series of 1,3-dithiazolylbenzene derivatives
Authors: Lagoja, IM ×
Nauwelaerts, Koen
Bal-Mahieu, C
Pasqualini, M
Bailly, C
Herdewijn, Piet #
Issue Date: 2004
Publisher: Inst organic chem and biochem
Series Title: Collection of Czechoslovak Chemical Communications vol:69 issue:7 pages:1491-1498
Abstract: By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl) amino] benzene derivatives 2 or 1,3-bis[2-iminothiazol-3(2H)-yl] benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a - 2d and 3a - 3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2.
URI: 
ISSN: 0010-0765
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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