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Title: Synthesis and structural study of 3,4-dihydro-2(1H)-pyridones and isoxazolo[5,4-b]pyridin-6(7H)-ones
Authors: Suarez, M ×
Verdecia, Y
Ochoa, E
Salfran, E
Moran, L
Martin, N
Martinez, R
Quinteiro, M
Seoane, C
Soto, JL
Novoa de Armas, Hector
Blaton, Norbert
Peeters, OM
De Ranter, Camiel #
Issue Date: Jun-2000
Publisher: Wiley-v c h verlag gmbh
Series Title: European journal of organic chemistry issue:11 pages:2079-2088
Abstract: A series of isoxazolo[5,4-b]pyridin-6(7H)-ones (8) have been prepared with a high stereochemical control from the novel 3,4-dihydro-2(1H)-pyridones (7) by reaction with hydroxylamine hydrochloride and subsequent 5-endo-trig cyclization. A structural study by X-ray analyses and theoretical calculations (AM1) of both heterocyclic systems (7 and 8) shows a favoured conformer with the aryl group on C4 in a pseudoaxial position. The same favoured conformation was found in solution according to NOE experiments and comparison of theoretical and experimental. coupling constants.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
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× corresponding author
# (joint) last author

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