Title: Characterization of solid dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion - part I
Authors: Verreck, Geert ×
Six, Karel
Van den Mooter, Guy
Baert, Lieven
Peeters, J
Brewster, ME #
Issue Date: Jan-2003
Publisher: Elsevier science bv
Series Title: International journal of pharmaceutics vol:251 issue:1-2 pages:165-174
Abstract: Solid dispersions containing different ratios of itraconazole and hydroxypropylmethylcellulose (HPMC) were prepared by solvent casting. Based on dose, differential scanning calorimetry and dissolution results, a drug/polymer ratio of 40/60 w/w was selected in order to prepare dispersions by melt extrusion. The melt extrusion process was characterized using a design of experiments (DOE) approach. All parameter settings resulted in the formation of an amorphous solid dispersion whereby HPMC 2910 5 mPa s prevents re-crystallization of the drug during cooling. Dissolution measurements demonstrated that a significantly increased dissolution rate was obtained with the amorphous solid dispersion compared to the physical mixture. The outcome of DOE further indicated that melt extrusion is very robust with regard to the itraconazole/HPMC melt extrudate characteristics. Stability studies demonstrated that the itraconazole/HPMC 40/60 w/w milled melt extrudate formulation is chemically and physically stable for periods in excess of 6 months as indicated by the absence of degradation products or re-crystallization of the drug. (C) 2002 Elsevier Science B.V. All rights reserved.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2003-Verreck-Characterization of solid dispersions.. Part I..-Int. J. of Pharm..pdf Published 208KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science