Title: The influence of ageing on the development and management of rheumatoid arthritis
Authors: Boots, Annemieke M H ×
Maier, Andrea B
Stinissen, Piet
Masson, Pierre
Lories, Rik #
De Keyser, Filip #
Issue Date: Oct-2013
Publisher: Nature Publishing Group
Series Title: Nature reviews. Rheumatology vol:9 issue:10 pages:604-613
Article number: 10.1038/nrrheum.2013.92
Abstract: The population of elderly individuals with rheumatoid arthritis (RA) is expanding, due mainly to increasing life expectancy. A variety of theories have been proposed to explain the ageing process, including accumulation of DNA damage and resultant changes in biological processes. Such changes can influence the development and/or course of disease. Furthermore, alterations in biological function determine the biological age-as opposed to chronological age-of an individual, which strongly influences their ability to cope with disease. Moreover, comorbidities are more frequent in elderly individuals. Together, these factors complicate treatment of disease and necessitate careful patient management. Indeed, although evidence from clinical trials suggests that DMARDs and biologic agents have good efficacy and are well tolerated in elderly patients with RA, such individuals are often undertreated and inadequately managed. Unfortunately, insufficient data are available for the development of evidence-based guidelines for this population, as elderly patients are often excluded from clinical trials owing to age restrictions or comorbidities. Thus, additional clinical studies in elderly patients are warranted, with treatment regimens tailored according to vitality or frailty parameters. This Review focuses on the pathophysiological aspects of ageing and their implications for the management of RA in elderly patients.
ISSN: 1759-4790
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Skeletal Biology and Engineering Research Center (+)
× corresponding author
# (joint) last author

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