Title: Dipole estimation errors due to not incorporating anisotropic conductivities in realistic head models for EEG source analysis
Authors: Hallez, Hans ×
Staelens, Steven
Lemahieu, Ignace #
Issue Date: Oct-2009
Publisher: IOP Pub.
Series Title: Physics in Medicine and Biology vol:54 issue:20 pages:6079-6093
Abstract: EEG source analysis is a valuable tool for brain functionality research and for
diagnosing neurological disorders, such as epilepsy. It requires a geometrical
representation of the human head or a head model, which is often modeled
as an isotropic conductor. However, it is known that some brain tissues, such
as the skull or white matter, have an anisotropic conductivity. Many studies
reported that the anisotropic conductivities have an influence on the calculated
electrode potentials. However, few studies have assessed the influence of
anisotropic conductivities on the dipole estimations. In this study, we want
to determine the dipole estimation errors due to not taking into account the
anisotropic conductivities of the skull and/or brain tissues. Therefore, head
models are constructed with the same geometry, but with an anisotropically
conducting skull and/or brain tissue compartment. These head models are
used in simulation studies where the dipole location and orientation error is
calculated due to neglecting anisotropic conductivities of the skull and brain
tissue. Results show that not taking into account the anisotropic conductivities
of the skull yields a dipole location error between 2 and 25 mm, with an
average of 10 mm. When the anisotropic conductivities of the brain tissues are
neglected, the dipole location error ranges between 0 and 5 mm. In this case,
the average dipole location error was 2.3 mm. In all simulations, the dipole
orientation error was smaller than 10◦. We can conclude that the anisotropic
conductivities of the skull have to be incorporated to improve the accuracy of
EEG source analysis. The results of the simulation, as presented here, also
suggest that incorporation of the anisotropic conductivities of brain tissues is
not necessary. However, more studies are needed to confirm these suggestions.
ISSN: 0031-9155
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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