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Title: Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke
Authors: De Reuck, J ×
Claeys, Ilse
Martens, Sven
Vanwalleghem, P
Van Maele, G
Phlypo, R
Hallez, Hans #
Issue Date: Apr-2006
Publisher: Rapid Communications
Series Title: European Journal of Neurology vol:13 issue:4 pages:402-407
Abstract: It is not well established whether seizures and epilepsy after an ischaemic stroke
increase the disability of patients. Seventy-two patients with delayed seizures after a
hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the
study. The modified Rankin scale was used to compare disability of the patients at
1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy.
The size of the X-ray hypoattenuation zone was compared on computed tomographic
(CT) scans, performed in the weeks after the stroke and 1 week after single or repeated
seizures. Lesion size was determined by superimposing the CT slices on digital cerebral
vascular maps, on which the contours of the infarct area were delineated. The extent of
the infarcts was expressed as the percentage fraction of the total surface area of the
cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually
compared. Infarcts predominated in the parieto-temporal cortical regions. In the
overall group the median Rankin score worsened significantly after seizures. The
average size of the X-ray hypoattenuation zone was also significantly increased on the
CT scans after the seizures, compared with those after stroke, without clear evidence
of recent infarction. Mutual comparison of patients with a single seizure episode and
of those with epilepsy showed only a trend of more severe disability and of increase in
lesion size in the post-stroke epilepsy group. Delayed seizures and epilepsy after is-
chaemic stroke are accompanied by an increase in lesion size on CT and by worsening
of the disability of the patients. This study does not allow to determine whether this is
due to stroke recurrence or due to additional damage as a result of the seizures
themselves.
ISSN: 1351-5101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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