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Title: Predictors of neonatal morbidity in fetuses with severe isolated congenital diaphragmatic hernia undergoing fetoscopic tracheal occlusion
Authors: Done', Elisa ×
Gratacos, Eduard
Nicolaides, Kypros
Allegaert, Karel
Valencia, Catalina
Castañon, Montserrat
Martinez, Josep-Maria
Jani, Jacques
Van Mieghem, Tim
Greenough, Anna
Gomez, Olga
Lewi, Paul
Deprest, Jan #
Issue Date: Jul-2013
Publisher: Blackwell Science
Series Title: Ultrasound in Obstetrics & Gynecology vol:42 issue:1 pages:77-83
Article number: 10.1002/uog.12445
Abstract: OBJECTIVES: To report the neonatal morbidity in fetuses with severe congenital diaphragmatic hernia (CDH) treated with fetoscopic endoluminal tracheal occlusion (FETO) and compare it with historical controls with less severe forms that were managed expectantly. METHODS: This is a prospective multicenter study on neonatal outcomes and prenatal predictors in 90 FETO survivors (78 left, 12 right) and 41 controls from the antenatal CDH registry with either severe or moderate hypoplasia who were managed expectantly. We also investigated early neonatal morbidity indicators, including need for patch repair, duration of mechanical ventilation and supplemental oxygen, age at full enteral feeding and incidence of pulmonary hypertension. RESULTS: Gestational age at delivery was predictive of duration of assisted ventilation (p=0.046), days on supplemental oxygen (p=0.019) and age at full enteral feeding (p=0.020). When delivery took place after 34 weeks, neonatal morbidity of FETO cases was comparable to that of expectantly managed cases with moderate hypoplasia. CONCLUSIONS: Fetal intervention for severe CDH is associated with a neonatal morbidity that is comparable to that of an expectantly managed group with less severe disease.
ISSN: 0960-7692
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

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