Healthy birth after testicular extraction of sperm and ICSI from an azoospermic man with mild androgen insensitivity syndrome caused by an androgen receptor partial loss-of-function mutation
Massin, Nathalie × Bry, Hélène Vija, Lavinia Maione, Luigi Constancis, Elizabeth Haddad, Bassam Morel, Yves Claessens, Frank Young, Jacques #
Blackwell Scientific Publications
Clinical Endocrinology vol:77 issue:4 pages:593-8
The androgen receptor (AR) is essential for the development and maintenance of the male phenotype, and for spermatogenesis. Mutations in the AR gene cause a wide variety of androgen insensitivity syndromes (AIS), ranging from complete feminization to phenotypic males with infertility.