Title: Pyridazine derivatives. Part 21: Synthesis and structural study of novel 4-aryl-2,5-dioxo-8-phenylpyrido[2,3-d]pyridazines
Authors: Pita, B ×
Sotelo, E
Suarez, M
Ravina, E
Ochoa, E
Verdecia, Y
Novoa de Armas, Hector
Blaton, Norbert
De Ranter, Camiel
Peeters, OM #
Issue Date: Apr-2000
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:56 issue:16 pages:2473-2479
Abstract: New substituted 4-aryl-2,5-dioxo-8-phenylpyrido[2,3-d]pyridazines 4a-f have been prepared in one step from the corresponding arylidene substituted Meldrum's acid (1) and 5-amino-6-phenyl-3(2H)-pyridazinone (2) in good yields. Semiempirical theoretical calculations (AM1) reveal two favoured conformations (A and B) for compounds 4a-f, with a screw boat conformation in the pyridone system and a planar pyridazinone ring. X-Ray crystallographic analysis shows that in the solid state, conformation A bearing the phenyl ring in a pseudoaxial position is the most stable. Compounds 4a-f fulfil, from the structural point of view, all the requirements needed for exhibiting cardiotonic effects. (C) 2000 Elsevier Science Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biocrystallography
Electrical Engineering - miscellaneous
Administration Rectorial Services - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science