Title: Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis
Authors: Pannecouque, Christophe ×
Wigerinck, Piet
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Dec-1992
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:33 issue:49 pages:7609-7612
Abstract: Synthesis of dimeric nucleoside building blocks with a N-cyanoguanidine linkage was performed by reaction of 3'-amino-3'-deoxythymidine with S,S-dimethyl-N-cyanodithioimidocarbonate followed by reaction of the obtained isothiourea with 5'-amino-2,5'-dideoxynucleosides. These dimers were protected in the 5'-position and converted into their phosphoramidites. Oligonucleotides were synthesized using these building blocks.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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