Title: Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof
Authors: Novikov, Mikhail S ×
Babkov, Denis A
Paramonova, Maria P
Khandazhinskaya, Anastasia L
Ozerov, Alexander A
Chizhov, Alexander O
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
Seley-Radtke, Katherine L #
Issue Date: Jul-2013
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:21 issue:14 pages:4151-4157
Article number: 10.1016/j.bmc.2013.05.009
Abstract: HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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