International PhD & Research Day of the International Fine Particles Reasearch Institute (IFPRI) location:Universite de Liege date:30th June 2010
DEM in Biological Physics: Simulating Yeast Colony Growth
To gain deeper understanding of the properties of biological systems such as cell colonies and tissues, modeling techniques are of utmost importance. Especially interest in the mechanical aspects of tissue/cultures is increasing because of the various important influences they have on life and death of the cells and the organism.
To simulate these structures, we choose an individual cell based, mesh-free modeling technique to ensure physically meaningful, directly measurable model parameters. In addition, we can use basic DEMeter++ code, a discrete elements methods software developed at MeBioS, KU Leuven.
The poster outlines the basic software design goals, main modeling ideas and the early stages of the validation of the model. We find the model suitable to describe the early growth of yeast micro-colonies.