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Title: Circulating CCL5 Levels in Patients with Breast Cancer: Is There a Correlation with Lymph Node Metastasis?
Authors: Smeets, Ann * ×
Brouwers, Barbara *
Hatse, Sigrid
Laenen, Annouschka
Paridaens, Robert
Floris, Giuseppe
Wildiers, Hans
Christiaens, Rose #
Issue Date: May-2013
Publisher: International Scholarly Research Network (I S R N)
Series Title: ISRN Immunology vol:2013
Article number: 453561
Abstract: CC-chemokine ligand 5 (CCL5) was measured in plasma of 238 patients with breast cancer and in serum of 149 of these patients.
Mean circulating CCL5 levels tended to be higher in patients with lymph-node-positive breast cancer, larger tumour sizes, the presence of lymphovascular invasion, and multifocal tumours. Additionally, circulating CCL5 levels were higher in the order of stages III, II, and I.The addition of circulatingCCL5 concentration to known clinicopathological predictors for lymph node involvement
did not allow more precise prediction of the lymph node status.These results suggest that CCL5 is a biomarker for tumour load rather than for lymph node involvement.As such, it might be helpful to identify patientswith escape fromimmunosurveillance who will benefit from therapies to restore immune function.
ISSN: 2090-5645
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Surgical Oncology
Laboratory of Experimental Oncology
Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat)
* (joint) first author
× corresponding author
# (joint) last author

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