Title: Defining pseudoprogression in glioblastoma multiforme
Authors: Van Mieghem, E ×
Wozniak, Agnieszka
Geussens, Y
Menten, Joannes
De Vleeschouwer, Steven
Van Calenbergh, Frank
Sciot, Raf
Van Gool, Stefaan
Bechter, Oliver #
Demaerel, Philippe
Wilms, Guy
Clement, Paul #
Issue Date: 20-Oct-2013
Publisher: Rapid Communications
Series Title: European Journal of Neurology vol:20 issue:10 pages:1335-1341
Article number: 10.1111/ene.12192
Abstract: BACKGROUND AND PURPOSE: Pseudoprogression is a frequent phenomenon observed since the introduction of postoperative therapy with radiotherapy and temozolomide (RT/TMZ) in glioblastoma multiforme (GBM) patients. However, the criteria defining pseudoprogression, its incidence, the time of occurrence and its impact on therapy and outcome remain poorly defined. METHODS: The objective of this study is to compare two sets of criteria (liberal and stringent), defining pseudoprogression, in a cohort of patients treated before and after the introduction of RT/TMZ in the standard postoperative treatment. This retrospective review includes 136 unselected and consecutively treated patients with pathologically diagnosed GBM. RESULTS: Pseudoprogression was observed in 10 (12%) cases applying the stringent criteria, and in 18 (23%) patients when using the liberal criteria, in the cohort treated with RT/TMZ. Pseudoprogression was observed in only one patient treated with RT alone. The median time to pseudoprogression was 4 weeks after the end of RT. Patients with pseudoprogression had a median survival time of 28 months, compared with 12 months for patients without pseudoprogression. CONCLUSIONS: The incidence of pseudoprogression after RT/TMZ strongly depends on the applied criteria. However, regardless of the stringency of the criteria, the impact on survival remains the same.
ISSN: 1351-5101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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