Title: Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies
Authors: Aguiar Alpizar, Yeranddy
Chain, Benjamin
Collins, Mary K
Greenwood, John
Katz, David
Stauss, Hans J
Mitchison, N Avrion # ×
Issue Date: Aug-2011
Publisher: Springer-Verlag
Series Title: Cancer Immunology, Immunotherapy vol:60 issue:8 pages:1127-35
Article number: 10.1007/s00262-011-0985-7
Abstract: Although cancer immunology has made vigorous progress over the last decade, its future remains uncertain. Tumors have clearly proved subject to immune surveillance, leading to antigenic editing, and means of activating both T and B arms of the immune system have been devised. Therapeutic vaccination and monoclonal antibody therapy have so far proved disappointing, because tumors prove adept at evasion from immune control. Dual targeting could well counteract evasion, provided that the two targets are independent and are attacked simultaneously. This stage has nearly but not quite been reached in several forms of immunotherapy, particularly of B-cell cancers, although such treatment also carries hazards.
ISSN: 0340-7004
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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